2008年(業績・論文)

21.
Nishizawa A, Nakano H, Satoh T, Takayama K, Sawamura D, Yokozeki H. Haber’s syndrome may be a clinical entity different from Dowling-Degos disease.
Br J Dermatol, 2008; 160(1): 215-217.

20.
Nakano H, Akasaka E, Rokunohe D, Yokoyama S, Toyomaki Y, Umegaki N, Mitsuhashi Y, Sawamura D. A novel homozygous missense mutation in the fatty aldehyde dehydrogenase gene causes Sjogren-Larsson syndrome. 
J Dermatol Sci 2008; 52(2): 136-138.

19.
Kivisaari AK, Kallajoki M, Mirtti T, McGrath JA, Bauer JW, Weber F, Konigova R, Sawamura D, Sato-Matsumura KC, Shimizu H, Csikos M, Sinemus K, Beckert W, Kahari VM.Transformation-specific matrix metalloproteinases (MMP)-7 and MMP-13 are expressed by tumour cells in epidermolysis bullosa-associated squamous cell carcinomas. 
Br J Dermatol 2008; 158(4): 778-85.

18.
Nomura T, Kodama K, Moriuchi R, Yaosaka M, Kawasaki H, Abe M, Sawamura D, Shimizu H.Papuloerythroderma of Ofuji associated with early gastric cancer. 
Int J Dermatol 2008; 47(6): 590-591.

17.
Nishie W, Sawamura D, Iitoyo M, Shimizu H.Intravascular histiocytosis associated with rheumatoid arthritis. 
Dermatology 2008; 217(2): 144-145.

16.
Takiyoshi N, Nakano H, Kaneko T, Aizu T, Nakajima K, Akasaka E, Rokunohe D, Sawamura D. Multiple desmoplastic trichoepitheliomas with ossification and cholesterol deposition. 
Exp Dermatol 2009; 34(5): 634-635.

15.
Minakawa S, Nakajima K, Aizu T, Nomura K, Kaimori K, A case of zosteriform metastatic skin cancer.
Clin Exp Dermatol 2008; 33(6): 808-810.

14.
Nagasaki A, Nishie W, Sato K, Oba I, Noguchi E, Akitsu H, Sawamura D, Shimizu H. Clinical and Genetic analysis of Fabry disease: report of 6 cases including 3 heterozygous females.
J Dermatol Sci 2008; 52(1): 61-64.

13.
Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T, Sawamura D. Vitamin D3 inhibits expression of pemphigus vulgaris antigen, desmoglein 3: implication of partial mechanism in pharmacological effect of VD3 on skin diseases. 
Mol Med Rep 2008; 1: 581-583.

12.
Kitamura H, Kaneko T, Nakano H, Terui H, Ito E, Sawamura D. Juvenile myelomonocytic leukemia presenting multiple painful erythematous lesions diagnosed as Sweet’s syndrome.
J Dermatol 2008; 35: 368-370.

11.
Kakizaki I, Itano N, Kimata K, Hanada K, Kon A, Yamaguchi M, Takahashi T, Takagaki KFUp-regulation of hyaluronan synthase genes in cultured human epidermal keratinocytes by UVB irradiation.
Arch Biochem Biophys 2008; 471(1): 85-93.

10.
Nanashima N, Akita M, Yamada T, Shimizu T, Nakano H, Fan Y, Tsuchida S.The Hairless Phenotype of the Hirosaki Hairless Rat Is Due to the Deletion of an 80-kb Genomic DNA Containing Five Basic Keratin Genes. 
J Biol Chem 2008; 283(24): 16868-16875.

9.
Nishizawa A, Nakajima R, Nakano H, Sawamura D, Takayama K, Satoh T, Yokozeki H. A de novo missense mutation in the keratin 13 gene in oral white sponge nevus.
Br J Dermatol 2008; 159(4): 974-975.

8.
Rokunohe A, Nakano H, Aizu T, Kaneko T, Nakajima K, Ikenaga S, Matsuzaki Y, Murai T, Tamai K, Sawamura D. Significance of sentinel node biopsy in the management of squamous cell carcinoma arising from recessive dystrophic epidermolysis bullosa.
J Dermatol 2008; 35(6): 336-340.

7.
Aizu T, Tamai K, Nakano H, Rokunohe D, Toyomaki Y, Uitto J, Sawamura D. Calcineurin/NFAT-Dependent Regulation of 230-kD Bullous Pemphigoid Antigen (BPAG1) Gene Expression in Normal Human Epidermal Keratinocytes.
J Dermatol Sci 2008; 51(1): 45-51.

6.
Nakajima K, Tamai K, Yamazaki T, Toyomaki Y, Nakano H, Uitto J, Sawamura D. Identification of Skn-1n, a splice variant that is induced by high calcium concentration and specifically expressed in normal human keratinocytes.
J Invest Dermatol 2008; 128(5): 1336-9.

5.
Rokunohe D, Nakano H, Ikenaga S, Umegaki N, Kaneko T, Matsuhashi Y, Tandoh Y, Toyoki Y, Hakamada K, Kusumi T, Harada K, SawamuraD. Reduction in epidermal Langerhans cells in patients with necrolytic migratory erythema.
J Dermatol Sci 2008; 50(1): 76-80.

4.
Nakajima K, Nakano H, Takiyoshi N, Rokunohe A, Ikenaga S, Aizu T, Kaneko T, Mitsuhashi Y, Sawamura D. Papillon-Lef?vre syndrome and malignant melanoma: a high incidence of melanoma development in Japanese palmoplantar keratoderma patients.
Dermatol 2008; 217(1): 58-62.

3.
Sato-Jin K, Nishimura EK, Akasaka E, Huber W, Nakano H, Miller A, Du J, Wu M, Hanada K, Sawamura D, Fisher DE, and Imokawa G. Epistatic connections between MITF and endothelin signaling in Waardenburg syndrome and other pigmentary disorders. 
FASEB J 2008; 22(4): 1155-68.

2.
Hamada T, Fukuda S, Ishii N, Sakaguchi S, Ishikawa T, Abe T, Yasumoto S, Hashimoto T, Nakano H, Sawamura D. Genotype-phenotype correlation in non-Hallopeau-Siemens recessive dystrophic epidermolysis bullosa: The splice site mutation c.6216+5G>T in the COL7A1 gene results in aberrant and normal splicings.
J Dermatol Sci 2008; 50(2): 147-50.

1.
Yamamoto C, Tamai K, Nakano H, Matsuzaki Y, Kaneko T, Sawamura D. Vitamin D(3) inhibits expression of bullous pemphigoid antigen 1 through post-transcriptional mechanism without new protein synthesis.
J Dermatol Sci 2008; 50(2): 155-158.

2007年(業績・論文)

24.
Abiko Y, Saitoh M, Nishimura M, Yamazaki M, Sawamura D, Kaku T.Role of beta-defensins in oral epithelial health and disease.
Med Mol Morphol 2007; 40(4): 179-184.

23.
Ota M, Nakazawa D, Sawamura D.Sarcoidosis manifesting as a periorbital purplish rash.
Am J Med 2007; 120(10): e3-4.

22.
Motoda N, Akiyama M, Aoyagi S, Sawamura D, Shimizu H.Low-grade myxofibrosarcoma invaded into the underlying skeletal muscle.
J Dermatol 2007; 34(8): 561-564.

21.
Yasukawa K, Sawamura D, Goto M, Nakamura H, Shimizu H.Histone deacetylase inhibitors preferentially augment transient transgene expression in human dermal fibroblasts.
Br J Dermatol 2007; 157: 662-669.

20.
Sakai K, Akiyama M, Sugiyama-Nakagiri Y, McMillan JR, Sawamura D, Shimizu H.Localization of ABCA12 from Golgi apparatus to lamellar granules in human upper epidermal keratinocytes.
Exp Dermatol 2007; 16: 920-926.

19.
Makino T, Nagasaki A, Furuichi M, Matsui K, Watanabe H, Sawamura D, Shimizu H, Shimizu T.Novel mutation in a fumalate hydr atase gene of a Japanese patient with multiple cutaneous and uterine leiomyomatosis.
J Dermatol Sci 2007; 48: 151-153.

18.
Yamanaka Y, Akiyama M, Sugiyama-Nakagiri Y, Sakai K, Goto M, McMillan JR, Ota M, Sawamura D, Shimizu H: Expression of the keratinocyte lipid transporter ABCA12 in developing and reconstituted human epidermis.
Am J Pathol 2007; 171: 43-52.

17.
Harada K, Tamai K, Nakano H, Sasaki C, Hanada K, Hashimoto I and Sawamura D: Inhibitory Effect of TGF-B on Expression of 230kD Bullous Pemphigoid Antigen
Hirosaki Med J 2007; 59: 7-14.

16.
Mayama M, Tamai K, Fukai K, Nakagawa T, Harada K, Nakano H, Hanada K, Hashimoto I and Sawamura D: Genotype and Phenotype Correlation of Dystrophic Epidermolysis Bullousa
Hirosaki Med J 2007; 59: 33-40.

15.
Murai T, Tamai K, Nakano H, Hanada K, Hashimoto I and Sawamura D: Novel COL7A1 mutations of Hallopeau-Siemens type recessive dystrophic epidermolysis bullosa 
Hirosaki Med J 2007; 59: 15-22.

14.
Nakano H, Toyomaki Y, Ohashi S, Nakano A, Jin H, Munakata T, Akita N, Tamai K, Mitsuhashi Y: Novel COL7A1 mutations in a Japanese family with transient bullous dermolysis of the newborn associated with pseudosyndactyly.
Br J Dermatol 2007; 157(1): 179-182.

13.
Nishizawa A, Toyomaki Y, Nakano A, Takeuchi S, Matsuzaki Y, Takeda H, Kaneko T, Mitsuhashi Y, Nakano H:A novel H1 domain mutation in the keratin 2 gene in a Japanese family with ichthyosis bullosa of Siemens.
Br J Dermatol 2007; 156(5): 1042-1044.

12.
Umegaki N, Tamai K, Nakano H, Moritsugu R, Yamazaki T, Hanada K, Katayama I, Kaneda Y: Differential regulation of karyopherin alpha 2 expression by TGF-beta1 and IFN-gamma in normal human epidermal keratinocytes: evident contribution of KPNA2 for nuclear translocation of IRF-1.
J Invest Dermatol 2007; 127(6): 1456-1464.

11.
Akiyama M, Sakai K, Sato T, McMillan JR, Goto M, Sawamura D, Shimizu H: Compound heterozygous ABCA12 mutations including a novel nonsense mutation underlie harlequin ichthyosis.
Dermatology 2007; 215(2): 155-159.

10.
Natsuga K, Sawamura D, Homma E, Nomura T, Abe M, Muramatsu R, Mochizuki T, Koike T, Shimizu H: Amicrobial pustulosis associated with IgA nephropathy and Sjogren’s syndrome.
J Am Acad Dermatol 2007; 57(3): 523-6.

9.
Abe M, Sawamura D, Goto M, Nakamura H, Nagasaki A, Nomura Y, Kawasaki H, Isogai R, Shimizu H: ITGB4 missense mutation in a transmembrane domain causes non-lethal variant of junctional epidermolysis bullosa with pyloric atresia.
J Dermatol Sci 2007; 47(2): 165-167.

8.
Hoshina D, Sawamura D, Nomura T, Tanimura S, Abe M, Onozuka T, Kodama K, Akiyama M, Shimizu H: Epidermolysis bullosa acquisita associated with psoriasis vulgaris.
Clin Exp Dermatol 2007; 32(5): 516-518.

7.
McMillan JR, Akiyama M, Tanaka M, Yamamoto S, Goto M, Abe R, Sawamura D, Shimomura M, Shimizu H: Small-Diameter Porous Poly (epsilon-Caprolactone) Films Enhance Adhesion and Growth of Human Cultured Epidermal Keratinocyte and Dermal Fibroblast Cells.
Tissue Eng 2007; 13(4): 789-798.

6.
Tsubota A, Akiyama M, Sakai K, Goto M, Nomura Y, Ando S, Abe M, Sawamura D, Shimizu H: Keratin 1 Gene Mutation Detected in Epidermal Nevus with EpidermolyticHyperkeratosis.
J Invest Dermatol 2007; 127(6): 1371-1374.

5.
Akiyama M, Sakai K, Arita K, Nomura Y, Ito K, Kodama K, McMillan JR,Kobayashi K, Sawamura D, Shimizu H: A Novel GJB2 Mutation p.Asn54His in a Patient with Palmoplantar Keratoderma, Sensorineural Hearing Loss and Knuckle Pads. 
J Invest Dermatol 2007; 127(6): 1540-1543.

4.
Sawamura D, Goto M, Sakai K, Nakamura H, McMillan JR, Akiyama M, Shirado O, Oyama N, Satoh M, Kaneko F, Takahashi T, Konno H, Shimizu H:  Possible Involvement of Exon 31 Alternative Splicing in Phenotype and Severity of Epidermolysis Bullosa Caused by Mutations in PLEC1.
J Invest Dermatol 2007; 127(6): 1537-1540.

3.
Nishie W, Sawamura D, Goto M, Ito K, Shibaki A, McMillan JR, Sakai K, Nakamura H, Olasz E, Yancey KB, Akiyama M, Shimizu H:  Humanization of autoantigen.
Nat Med 2007; 13(3): 378-383.

2.
Yamane N, Sawamura D, Nishie W, Abe M, Kodama K, Adachi K, Nakamura H, IshiiN, Hashimoto T, Shimizu H: Anti-p200 pemphigoid in a 17-year-old girl successfully treated with systemic corticosteroid and dapsone.
Br J Dermatol 2007; 156(5): 1075-1078.

1.
Kitamura H, Matsuzaki Y, Kimura K, Nakano H, Imaizumi T, Satoh K, Hanada K: Cytokine modulation of retinoic acid-inducible gene-1(RIG-1) expression in human epidermal keratinocytes. 
J Dermatol Sci 2007; 45: 127-134.

2006年(業績・論文)

26.
24Akiyama M, Sakai K, Wolff G, Hausser I, McMillan J, Sawamura D, Shimizu H: A novel ABCA12 mutation  3270delT causes harlequin ichthyosis.
Br J Dermatol 2006; 155(5): 1064-1066.

25.
Mayuzumi M, Akiyama M, Nishie W, Ukae S, Abe M, Sawamura D, Hashimoto T, Shimizu H: Childhood epidermolysis bullosa acquisita with autoantibodies against the noncollagenous 1 and 2 domains of type VII collagen: case report and review of the literature.
Br J Dermatol 2006; 155(5): 1048-1052.

24.
Akiyama M, Sakai K, Sugiyama-Nakagiri Y, Yamanaka Y, McMillan JR, Sawamura D, Niizeki H, Miyagawa S, Shimizu H: Compound heterozygous mutations including a de novo missense mutation in ABCA12 led to a case of harlequin ichthyosis with moderate clinical severity.
J Invest Dermatol 2006; 126(7): 1518-1523.

23.
Yokota K, Yamanaka Y, Furuya K, Sawamura D: Hailey-Hailey disease associated with affective disorder.
J Dermatol Sci 2006; 43(2): 150-151.

22.
Goto M, Sawamura D, Nishie W, Sakai K, McMillan JR, Akiyama M, Shimizu H: Targeted skipping of a single exon harboring a premature termination codon mutation: Implications and potential for gene correction therapy for selective dystrophic epidermolysis bullosa patients.
J Invest Dermatol 2006; 126: 2614-2620.

21.
Nakamura H, Sawamura D, Goto M, Nakamura H, Kida M, Ariga T, Sakiyama Y, Tomizawa K, Mitsui M, Tamaki T, Shimizu H: Analysis of the COL17A1 in non-Herlitz junctional epidermolysis bullosa and amelogenesis imperfecta.
Int J Mol Med 2006;18: 333-337.

20.
Sawamura D, Mochitomi Y, Kanzaki T, Nakamura N, Shimizu H: Glycine substitution mutations of different amino acids at the same codon in COL7A1 cause different modes of dystrophic epidermolysis bullosa inheritance.
Br J Dermatol 2006; 155: 834-837.

19.
Ujiie H, Sawamura D, Shimizu H: Development of lichen planus and psoriasis on lesions of vitiligo vulgaris.
Clin Exp Dermatol 2006; 31: 375-377.

18.
Yasukawa K, Sawamura D, Jung Sung-Yong, Goto M, Nakamura H, Kim S-C, Shimizu H: Epidermolysis bullosa simplex in Oriental; genetic studies in 19 patients.
Br J Dermatol 2006; 155: 313-317.

17.
Arita K, Akiyama M, Aizawa T, Umetsu Y, Segawa I, Goto M, Sawamura D, Demura M, Kawano K, Shimizu H: A Novel N14Y mutation in Connexin26 in keratitis-ichthyosis-deafness syndrome: analyses of altered gap junctional communication and molecular structure of N terminus of mutated Connexin26.
Am J Pathol 2006; 169(2): 416-423.

16.
Sawamura D, Niizeki H, Miyagawa S, Shinkuma S, Shimizu H: A novel indel COL7A1 mutation 8068del17insGA causes dominant dystrophic epidermolysis bullosa.
Br J Dermatol 2006; 154: 995-997.

15.
Sawamura D, Sato-Matsumura K, Shibata S, Tashiro A, Frue M, Goto M, Akiyama M, Nakamura H, Shimizu H: COL7A1 mutation G2037E causes epidermal retention of type VII collagen.
J Hum Genet 2006; 51: 418-420.

14.
Onozuka T, Sawamura D, Goto M, Yokota K, Shimizu H: Possible role of endoplasmic reticulum stress in the pathogenesis of Darier’s disease.
J Dermatol Sci 2006; 41: 217-220.

13.
Ota M, Sawamura D, Yokota Y, Ueda M, Horiguchi Y, Kodama K, Goto M, Shimizu H: A unique monoclonal antibody 29A staining the cytoplasm of amniotic epithelial in the placenta and cutaneous basement membrane zone.
J Dermatol Sci 2006; 42: 23-29.

12.
Goto M, Sawamura D, Ito K, Abe M, Nishie W, Sakai K, Shibaki A, Akiyama M, Shimizu H: Fibroblasts show more potential target cells than keratinocytes for COL7A1 gene therapy of dystrophic epidermolysis bullosa.
J Invest Dermatol 2006; 126: 766-772.

11.
Yanagi T, Sawamura D, Nishie W, Abe M, Shibaki A, Shimizu H: Multiple apocrine hidrocystoma showing plane pigmented macules.
J Am Acad Dermatol 2006; 54: S53-S54.

10.
Tanimura S, Arita K, Iwao F, Kasai M, Fujita Y, Kawasaki H, Abe R, Sawamura D, Kimura T, Shimizu H: Two cases of folliculosebaceous cystic hamartoma the clinical and histopathologic differential points between folliculosebaceous cystic hamartoma and sebaceous trichofolliculoma.
Clin Exp Dermatol 2006; 31: 68-70.

9.
Nakano H, Nakano A, Toyomaki Y, Ohashi S, Harada K, Moritsugu R, Takeda H, Kawada A, Mitsuhashi Y, Hanada K: Novel ferrochelatase mutations in Japanese patients with erythropoietic Protoporphyria: High frequency of the splice site modulator IVS3-48C polymorphism in the Japanese population.
J Invest Dermatol 2006; 126: 2717-2719.

8.
Kondo N, Takeda H, Kaneko T, Aizu T, Moritsugu R, Kon A, Nakano H, Hanada K: A method for rapid evaluation of photoaging by measuring fluorescence intensity of green fluorescent protein due to elastin promoter activity.
J Dermatol Sci 2006: Suppl(2); 31-37.

7.
Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A: Muir-torre syndrome with intriguing squamous lesions: a case report and review of the literature.
Am J Dermatopathol 2006; 28(1): 56-59.

6.
Ikenaga S, Nakano H, Umegaki N, Moritsugu R, Aizu T, Kuribayashi M, Hanada K: A case of bullous dermatitis artefacta possibly induced by a deodorant spray. 
J Dermatol 2006; 33(1): 40-42.

5.
Kaneko T, Tamai K, Matsuzaki Y, Yamazaki T, Nakano H, Kon K, Hashimoto I, Hanada K, Kaneda Y, Uitto J:Interferon-gamma down-regulates expression of the 230-kDa bullous pemphigoid antigen gene (BPAG1) in epidermal keratinocytes via novel chimeric sequences of ISRE and GAS. 
Exp Dermatol 2006; 15(4): 308-314.

4.
Jiang Q, Matsuzaki Y, Li K, Uitto J:Transcriptional regulation and characterization of the promoter region of the human ABCC6 gene. 
J Invest Dermatol 2006; 126: 325-335.

3.
Nishizawa A, Nakanishi Y, Sasajima Y, Yamazaki N, Yamamoto A: Syringoid eccrine carcinoma with apparently aggressive transformation: case report and review of the literature.
International Journal of Dermatology 2006; 45: 1218-1221.

2.
Kambe Y, Nakano H, Kaneko T, Aizu T, Ikenaga S, Harada K, Nakajima K, Moritsugu R, Hanada K: Giant pilomatricoma associated with hypercalcemia and elevated levels of parathyroid hormone-related protein. 
Br J Dermatol 2006; 155: 208-210.

1.
Nakano H, Ikenaga S, Aizu T, Kaneko T, Matsuzaki Y, Tsuchida S, Hanada K, Arima Y: Human metallothionein gene expression is upregulated by β-thujaplicin:possible involvement of protein kinase C and reactive oxygen species. 
Biol Pharm Bull 2006; 29(1): 55-59.

2005年(業績・論文)

32.
Ken Harada, A. Bemard Ackerman:Less than 10% of primary cutaneous melanomas, worldwide, are associated with a melanocytic nevus and that nevus usually is congenital, not“dysplastic”.
Dermatopathology, 2005; 11(2): 14.

31.
Nanashima N, Asano J, Hayakari M, Nakamura T, Nakano H, Yamada T, Shimizu T, Akita M, Fan Y, and Tsuchida S. Nuclear Localization of STAT5A Modified with O-Linked N-Acetylglucosamine and Early Involution in the Mammary Gland of Hirosaki Hairless RAT*. 
Journal of Biological Chemistry, 2005; 280(52): 43010-43016 .

30.
Sawamura D, Goto M, Yasukawa K, Sato-Matsumura K, Nakamura H, Ito K, Nakamura H, Tomita Y, Shimizu H: Genetic studies of 20 Japanese families of dystrophic epidermolysis bullosa.
J Hum Genet, 2005; 50: 543-546.

29.
Yanagi T, Sawamura D, Shibaki A, Shimizu H: Treatment for poikilodermatous erythema of dermatomyositis with the pulsed dye laser (SPTL-1b).
Br J Dermatol, 2005; 153: 862-864.

28.
Akiyama M, Sugiyama-Nakagiri Y, Sakai K, McMillan JR, Goto M, Arita K, Tsuji-Abe Y, Tabata N, Matsuoka K, Sasaki R, Sawamura D, Shimizu H: Mutations in ABCA12, a keratinocyte lipid transporter, in harlequin ichthyosis and functional recovery by corrective gene transfer.
J Clin Invest, 2005; 115: 1777-1784.

27.
Abe M, Sawamura D, Ito S, Nishio H, Yoshida H, Shimizu H: Herpes simplex virus and cytomegalovirus coexist with perianal ulcer in an idiopathic thrombocytopenic purpura patient.
Clin Exp Dermatol, 2005; 30: 596-598.

26.
Horiguchi Y, Sawamura D, Mori R, Nakamura H, Takahashi K, Shimizu H: Clinical heterogeneity of 1649delG mutation in the tail domain of keratin 5: a Japanese family with epidermolysis bullosa simplex with mottled pigmentation. 
J Invest Dermatol, 2005; 125: 83-85.

25.
Sawamura D, Ohata Y, Shibaki A, Shimizu H: Pigmented purpuric dermatosis in mixed cryoglobulinemia associated with rheumatoid arthritis and hepatitis C infection.
Acta Derm Venereol, 2005; 85: 440-461.

24.
Yaosaka M, Sawamura D, Iitoyo M, Shibaki A, Shimizu H: Lichen striatus affecting a mother and her son.
J Am Acad Dermatol, 2005; 53, 352-353.

23.
Ujiie H, Sawamura D, Yokota K, Tateishi Y, Inokuma D, Shimizu H: Intractable erythema nodosum associated with severe breast abscesses : report of two cases.
Clin Exp Dermatol, 2005; 30: 584-585.

22.
Ujiie H, Sawamura D, Shibaki A, Shimizu H. Prolonged dermatitis distant to the site of squaric acid dibutyl ester applications and recovery of alopecia areata.
Clin Exp Dermatol, 2005; 30: 579-580.

21.
Sawamura D, Goto M, Shibaki A, Akiyama M, McMillan JR, Abiko Y, Shimizu H: Beta defensin-3 engineered epidermis shows highly protective effect for bacterial infection.
Gene Ther, 2005; 12: 857-861.

20.
Akiyama M, Tsuji-Abe Y, Yanagihara M, Nakajima K, Kodama H, Yaosaka M, Abe M, Sawamura D, Shimizu H: Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing.
Br J Dermatol, 2005; 152: 1353-1356.

19.
Sawamura D, Sato-Matsumura KC, Shibaki A, Akiyama M, Kikuchi T, Shimizu H: A case of lichen amyloidosis treated with pulsed dye laser.
J Eur Acad Dermatol, 2005; 19: 262-263.

18.
Ota M, Sawamura D, Shibaki A, Shimizu H: Bone marrow clonal T-cell population in lymphomatoid papulosis.
J Am Acad Dermatol, 2005; 52: 710-711.

17.
Yasukawa K, Sawamura D, Sugawara H, Kato N: Leuprorelin acetate granulomas; case reports and review of the literature.
Br J Dermatol, 2005; 152: 1045-1047.

16.
Sawamura D, Abe R, Goto M, Akiyama M, Hemmi H, Akira S, Shimizu H: Direct injection of plasmid DNA into the skin induces dermatitis by activation of monocytes through toll-like receptor 9.
J Gene Med, 2005; 7: 664-671.

15.
Nakamura H, Sawamura D, Goto M, Nakamura H, McMillan JR, Park S, Kono S, Hasegawa S, Paku S, Nakamura T, Ogiso Y, Shimizu H: Mutations in the plectin gene (PLEC1) cause a novel clinical subtype epidermolysis bullosa simplex associated with pyloric atresia.
J Mol Diagn, 2005; 7: 28-35.

14.
Ota M, Sato-Matsumura KC, Sawamura D, Shimizu H: Papuloerythroderma associated with hepatitis C virus infection. 
J Am Acad Dermatol, 2005; 52: 61-62.

13.
Kawasaki H, Sawamura D, Nakazawa H, Hattori N, Goto M, Sato-Matsumura KC, Akiyama M, Shimizu H: Detection of 1733insC mutations in an Asian family with Birt-Hogg-Dube syndrome.
Br J Dermatol, 2005; 152: 142-145.

12.
Yasukawa K, Sawamura D, Akiyama M, Motoda N, Shimizu H: Keratotic lesions in epidermolysis bullosa simplex with mottled pigmentation.
J Am Acad Dermatol, 2005; 52: 172-173.

11.
Yokoyama S, Nakano H, Nishizawa A, Kaneko T, Harada K, Hanada K: A case of photocontact urticaria induced by photodynamic therapy with topical 5-aminolaevulinic acid.
J Dermatol, 2005; 32(10): 843-847.

10.
Nishizawa A, Nakanishi Y, Yoshimura K,Sasajima Y, Yamazaki N, Yamamoto A, Hanada K, Kanai Y, Hirohashi S: Clinicopathologic significance of dysadherin expression in cutaneous malignant melanoma.Immunohistochemical Analysis of 115 patients. 
Cancer, 2005; 103(8): 1693-1700.

9.
Kon A, Takeda H, Ito N, Hanada K, Takagaki K: Tissue-specific downregulation of type Ⅶ collagen gene (COL7A1) transcription in cultured epidermal keratinocytes by ultraviolet a radiation (UVA) and UVA-inducible cytokines, with spcial reference to cutaneous photoaging. 
J Dermatol Sci, 2005; Suppl.1: 29-35.

8.
Yokoyama S, Nakano H, Yamazaki T, Tamai K, Hanada K, Takahashi G: Enhancement of ultraviolet-induced apoptosis by NF-κB decoy oligonucleotides. 
Br J Dermatol, 2005; 153(Suppl.2): 47-51.

7.
Matsuzaki Y, Nakano A, Jiang Q, Pulkkinen L, Uitto J: Tissu-specific expression of the ABCC6 gene.
J Invest Dermatol, 2005; 125: 900-905.

6.
Hata D, Miyazaki M, Seto S, Kadota E, Muso E, Takasu K, Nakano A, Tamai K, Uitto J, Nagata M, Moriyama K, Miyazaki k: Nephrotic syndrome and aberrant expression of laminin isoforms in glomerular basement membranes for an infant with Herlitz junctional epidermolysis bullosa. 
Pediatrics, 2005; 116(4): 601-607.

5.
Takeda H, Kaneko T, Harada K, Matsuzaki Y, Nakano H, Hanada K: Successful treatment of lymphadenosis benigna cutis with topical photodynamic therapy with delta-aminolevulinic acid. 
Dermatol, 2005; 211: 264-266.

4.
Klement J, Matsuzaki Y, Jiang Q, Terlizzi J, Choi H, Fujimoto N, Li K, Pulkkinen L, Birk D, Sundberg J, Uitto J: Targeted ablation of the Abcc6 gene results in ectopic mineralization of connective tissues. 
Mol. Cell. Biol, 2005; 25(18): 8299-8310.

3.
Takeda H, Kon A, Ito N, Sawamura D, Takagaki K, Hashimoto I, Hanada K: Keratinocyte-specific modulation of typeⅦ collagen gene expression by pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β).
Experimental Dermatology, 2005; 14: 289-294.

2.
Wakabayashi T, Hu D, Tagawa Y, Sekikawa K, Iwakura Y, Hanada H, Nakane A: INF-γ and TNF-α are involved in urushiol-induced contact hypersensitivity in mice. 
Immunology and Cell Biology, 2005; 83: 18-24.

1.
Yokoyama S, Nakano H, Kaneko T, Hanada K: A Japanese case of nuchal-type fibroma. 
J Dermatol, 2005; 32(11): 931-2.

2004年(業績・論文)

17.
Yasukawa K, Shimizu S, Yasui C, Sawamura D, Tsuchiya K. Cutaneous adenocarcinoma metastases of unknown origin associated with swelling of the neck and cheeks with indurated erythema.
Acta Derm Venereol, 2004; 84: 399-400.

16.
Abe Y, Akiyama M, Nakamura H, Takizawa Y, Sawamura D, Matsunaga K, Suzumori K, Shimizu H: DNA-based prenatal exclusion of bullous congenital ichthyosiform erythroderma at the early stage, 10-11 weeks’ of pregnancy in two consequent siblings.
J Am Acad Dermatol, 2004; 51: 1008-1011.

15.
Goto M, Sato-Matsumura KC, Sawamura D, Yokota K, Nakamura H, Shimizu H: Tyrosinase gene analysis in Japanese patients with oculocutaneous albinism.
J Dermaol Sci, 2004; 35: 215-220.

14.
Yanagi T, Sawamura D, Shimizu H: Follicular mucinosis associated with imatinib (STI571). 
Br J Dermatol, 2004; 151: 1276-1278.

13.
Akiyama M, Matsuo I, Sawamura D, Shimizu H: Remodeling of desmosomal and hemidesmosomal adhesion systems during human hair follicle development.
J Dermatol Sci, 2004; 35: 154-157.

12.
Sawamura D, Ina S, Goto M, Akiyama M, Shimizu H: In vivo transfer of TGF-alpha and beta genes to keratinocytes. 
J Dermaol Sci, 2004; 34: 234-236.

11.
Nakamura H, Sawamura D, Goto M, Sato-Matsumura KC, LaDuca J, Lee JYY, Masunaga T, Shimizu H: The G2028R glycine substitution mutation in COL7A1 leads to marked inter-familiar clinical heterogeneity in dominant dystrophic epidermolysis bullosa.
J Dermaol Sci, 2004; 34: 195-200.

10.
Ujiie H, Sawamura D, Yokota K, Nishie W, Shichinohe R, Shimizu H: Pyoderma gangrenosum associated with Takayasu’s arteritis: case report and review of the literature.
Clin Exp Dermatol, 2004; 29: 357-359.

9.
Hata H, Sawamura D, Shibaki A, Shimizu H: Facial erythema alone as a manifestation of chronic graft-versus-host disease.
Acta Derm Venereol, 2004; 84: 239-240.

8.
Nishie W, Sawamura D, Mayuzumi M, Takahashi S, Shimizu H: Hidradenoma papilliferum with mixed histopathologic features of syringocystoadenoma papilliferum and anogenital mammary-like glands.
J Cutan Pathol, 2004; 31: 561-564.

7.
Kotani N, Kudo R, Sakurai Y, Sawamura D, Sessier D, Okada H, Nakamura H, Yamagata T, Yasujima M, Matsuki A: Cerebrospinal fluid interleukin8 concentration at healing of a herpetic rash best predicts intractable postherpetic neuralgia.
Am J Med, 2004; 116: 318-324.

6.
Iwao F, Sato-Matsumura KC, Sawamura D, Shimizu H: Elephantiasis nostras verrucosa successfully treated by surgical debridement.
Dermatol Surg, 2004; 30: 939-941.

5.
Onzuka T. Sawamura D, Yokota Y, Shimizu H: Mutations analysis of ATP2A2 gene in two Darier’s disease pedigrees with marked different clinical severity within affected family members.
Br J Dermatol, 2004; 150: 652-657.

4.
Yamazaki T, Nakano H, Hayakari M, Tanaka M, Mayama J, Tsuchida S: Differentiation Induction of Human Keratinocytes by Phosphatidylethanolamine-Binding Protein. 
J Biol Chem, 2004; 279(31): 32191-32195.

3.
Odanagi M,Kikuchi Y,Yamazaki T,Kaneko T,Nakano H,Tamai K,Uitto J,Hanada K: Transcriptional regulation of the 230-kDa bullous pemphigoid antigen gene expression by interferon regulatory factor 1 and interferon regulatory factor 2 in normal human epidermal keratinocytes.
Experimental Dermatology, 2004; 13: 773-779.

2.
Kikuchi T,Mitsuhashi Y,Matsuzaki Y,Kaneko T,Nakano H,Takeda H,Moritsugu R,Hanada K: Altered keratinocyte-fibroblast interactions in psoriasis revealed by a combined cell-culture.
Hirosaki Med J, 2004; 56(1): 1-8.

1.
Harada K, Kambe Y, Takeda H, Nakano H, Hanada K: Angiolymphoid Hyperplasia with Eosinophilia: Successful Treatment with the Antiallergic Agent Suplatast Tosilate. 
Dermatology, 2004; 208: 176-177.

2003年(業績・論文)

23.
Nishie W, Yokota K, Sawamura D, Sato-Matsumura K, Tanimura S, Osawa R, KawashimaT, Yokota T, Shimizu H: Detection of circulating lymphoma cells in subcutaneous panniculitis-like T-cell lymphoma.Br J Dermatol, 2003; 149: 1081-1082.

22.
Akiyama M, Sawamura D, Shimizu H: Truncation of CGI-58 protein causes malformation of lamellar granules resulting in ichthyosis in Dorfman-Chanarin syndrome.J Invest Dermatol, 2003; 121: 1029-1034.

21.
Akiyama M, Sawamura D, Shimizu H: The clinical spectrum of non bullous congenital ichthyosiform erythroderma and lamellar ichthyosis.Clin Exp Dermatol, 2003; 28: 235-240.

10.
Tomita Y, Sato-Matsumura KC, Sawamura D, Matsumura T, Shimizu H: The simultaneous occurrence of three independent squamous cell carcinomas in a recessive dystrophic epidermolysis bullosa patient.Acta Derm Venereol, 2003; 83: 225-226

19.
Sato-Matsumura KC, Sawamura D, Goto M, Goto, Nakamura H, Shimizu H: A novel paternal four base pairs insertion and a maternal nonsense point mutation in COL7A1 identified in Hallopeau-Siemens recessive dystrophic epidermolysis bullosa.Acta Derm Venereol, 2003; 83: 137-138.

18.
Iwao F, Sawamura D, Yokota K, Shimizu H: Granulomatous blepharitis successfully treated with Tranilast.Br J Dermatol, 2003; 149: 222-224.

17.
Sawamura D, Goto M, Yasukawa K, Kon A, Akiyama M, Shimizu H: Identification of COL7A1 alternative splicing inserting 9 amino acid residues into the fibronectin type III linker domain.J Invest Dermatol, 2003; 120: 942-948.

16.
Akiyama M, Takizawa Y, Sawamura D, Matsuo I, Shimizu H: Disruption of suprabasal keratin network by mutation M150T in the helix initiation motif of keratin 10 does not affect cornified cell envelope formation in human epidermis.Exp Dermatol, 2003; 12: 628-645.

15.
Kawasaki H, Sawamura D, Iwao F, Kikuchi T, Nakamura H, Okubo S, Matsumura T, Shimizu H: Squamous cell carcinoma developed in a 12-year-old boy with non-Hallopeau-Siemens recessive dystrophic epidermolysis bullosa.Br J Dermatol, 2003; 148: 1047-1050.

14.
Sawamura D, McMillan JR, Akiyma M, Shimizu H: Epidermolysis bullosa: directions for future research and new challenges for treatment.Arch Dermatol Res, 2003; 295: S34-S42.

13.
Hanada K: Photoprotective role of mettalothionein in UV-injury metallothionein-null mouse exhibits reduced tolerance against ultraviolet-B.J Deramtol Sci, 2000; 23(Suppl.1): S51-S56.

12.
Tamai K, Hshimoto I, Hanada K, Shigaku Ikeda, Sadao Imamura, Hideoki Ogawa: Japanese guidelines for diagnosis and treatment of junctional and dystrophic epidermolysis.Arch dermatol Res, 2003; 295(suppl 1): 42-45.

11.
Umegaki N, Moritsugu R, Katoh S, Harada K, Nakano H, Tamai K, Hanada K, Tanaka M: Photodynamic therapy may be useful in debulking cutaneous lymphoma prior to radiotherapy.Clin Exp dermatol, 2004; 29: 42-45.

10.
Matsuyama A. Nakano H, Harada K, Yamazaki T, Kanno T, Wakui M, Hanada K: Enhancement of photodynamic effect in normal rat keratinocytes by treatment with 1,25 dihydroxy vitamin D3.Photodermatol Photoimmunol Photomed, 2003; 19: 303-308.

9.
Mayama J, Kumano T, Hayakari M, Yamazaki T, Aizawa S, Kudo T, Tsuchida S: Polymorphic glutathione S-transferase subunit 3 of rat liver exhibits different susceptibilities to carbon tetrachloride: differences in their interactions witth heat-shock protein 90.Biochem J, 2003; 372: 611-616

8.
Sasaki H, Kon A, Takeda H, Sawamura D, Kakizaki I, Takagaki K, Hashimoto I, Hanada K: A novel Sp1-family-related cis-acting element for transcription of type Ⅶ Collagen gene (COL7A1).J Dermatol Sci, 2003; 32(3): 239-242.

7.
Nakano A, Nakano H, Nomura K, Toyomaki Y, Hanada K: Novel SLC39A4 mutations in acrodermatitis enteropathica.J Invest Dermatol, 2003; 120(6): 963-966.

6.
Kaneko T, Tamai K, Yamazaki T, Harada K, Nakano H, Hanada K: Superficial granulomatous pyoderma: A case report of two Japanese patients and clinical comparison with foreign patients.J Dermatol, 2003; 30(6): 472-476.

5.
Sawamura D, Goto M, Yasukawa K, Kon A, Akiyama M, Shimizu H: Identifin of COL7A1 alternative splicing inserting 9 amino acid residues intothe fibronectin type Ⅲ linker domain.J Invest Dermatol, 2003; 120(6): 942-948.

4.
Pfendner E G (Jefferson), Nakano A (Jefferson, Hirosaki), Pulkkinen L (Jefferson), Christiano A M(Columbia University), Uitto J (Jefferson): Prenatal diagnosis for epidermolysis bullosa: a study of 144 consecutive pregnanciesat risk.Prenat Diagn, 2003; 23(6): 447-456.

3.
Matsuzaki Y, Tamai K, Kon A, Sawamura D, Uitto J, Hashimoto I: keratinocyte responsive element 3: Analysis of a keratinocytespecific regulatory sewuence in the 230-kDa Bullous pemphigoid antigen gene promoter.J Invest Dermatol, 2003; 120(2): 308-312.

2.
Mizuki D, Kaneko T, Hanada K: Successful treatment of topical photodynamic therapy using 5-aminolevulinic acid for plance warts.Br J Dermatol, 2003; 149(5): 1087-1088.

1.
Kon A, Takeda H, Sasaki H, Yoneda K, Nomura K, Ahvazi B, Peter M.Steinert, Hanada K, Hashimoto I: Novel transglutaminase 1 gene mutations(R348X/Y365D) in a Japanese family with lamellar ichthyosis.J Invest Dermatol, 2003; 120(1): 170-172 .

2002年(業績・論文)

9.
Sawamura D, Umeki K. Ulcerative colitis associated with digitate dermatitis
Clin Exp Dermatol, 2002; 27: 716-717.
8.
Sawamura D, Akiyama M, Shimizu H: Direct injection of naked DNA and cytokine transgene expression: implications for keratinocyte gene therapy.
Clin Exp Dermatol, 2002; 27: 480-484.
7.
Yasukawa K, Sawamura D, McMillan JR, Nakamura H, Shimizu H: Dominant and recessive compound heterozygous mutations in epidermolysis bullosa simplex demonstrate the role of the stutter region in keratin intermediate filament assembly.
J Biol Chem, 2002; 277: 23670-23674.
6.
Sawamura D, Yasukawa K, Kodama K, Yokota K, Sato-Matsumura KC, Tanaka T, Shimizu H: The majority of keratinocytes incorporate intradermally injected plasmid DNA regardless of size but only a small proportion of cells can express the gene product.
J Invest Dermatol, 2002; 118: 967-971.
5.
Nakamura H, Aoki M, Tamai K, Oishi M, Ogihara T, Kaneda Y, Morishita R: Prevention and regression of atopic dermatitis by ointment containing NF-kB decoyoligodeoxynucleotides in NC/Nga atopic mouse model.
Gene therapy, 2002; 9: 1221-1229.
4.
Meng X, Sawamura D, Ina S, Tamai K, Hanada K, Hashimoto I. Keratinocyte gene therapy: cytokine gene expression in local keratinocytes and in circulation by introducing cytokine genes into skin.
Exp Dermatol, 2002; 11: 456-461.
3.
Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, Nishi N, Fujimoto K, Tanji K, Shibata T, Tamo W, Matsumiya T, Yoshida H, Cui X, Takanashi S, Hanada K, Okumura K, Yagihashi S, Wakabayashi K, Nakamura T, Hira M, Satoh K: Interferon-γ stimulates the expression of galectin-9 cultured human endothelial cells.
Journal of Leukocyte Biology, 2002; 72: 486-491.
2.
Mizuki D, Mizuki M, Nakano H, Hanada K:Successful treatment of topical photodynamic therapy using 5-aminolevulinic acid for lymphadenosis benigna cutis.
J Photosci, 2002; 9: 506-508.
1.
Nakano A, Gilles G. Lestringant (Tawam Medical Center, UAE), Tamar Paperma,Reuven Bergman, Ruth Gershoni (Rambam Medical Center, Israel), Philippe Frossard (Tawam Medical Center, UAE), Moien Kanaan (Bethlehem University,West Bank), Guerrino Meneguzzi (INSERM, France), Gabriele Richard, Ellen Pfendner, Jouni Uitto, Leena Pulkkinen, Eli Sprecher (Jefferson University):Junctionalepidermolysis bullosa in the middle east: clinical and genetic studies in a seriesof consanguineous families.
J Am Acad Dermatol, 2002; 46(4): 510-516.